Practically speaking, it will not work. In the case of a two cell system, you would be putting the cells in parallel when the switch was activated. If the two cells where of the same type and age, you might be O.K. After all, Surefire parallels up three pair of CR123's in the M6.
But if the cells were not relatively close in voltage and internal impedance, the stronger of the two cells would be drained slightly by trying to charge the weaker cell. Naturally, you won't 'see' any of this happening, as the bulb will have 0 volts applied to it.
For systems where you have more than two cells, the voltage applied to the bulb during discharge will be 'N-2', where N=number of cells. If you had a five cell system and reversed one of the cells, the reversed cell would cancel one cell, leaving the remainder to power the bulb. (5 minus 2 equals 3)
If you are worried about the switch turning on during a period of long term storage, I would suggest inserting some type of insulator on the last cell. A nylon washer or even a heavy grade of craft paper should do the trick.