It depends on what you're trying to accomplish and what you're trying to replace.
Efficiency? Focus on lumens per watt. More lumens per watt = more efficient bulb
Colour rendering/how good things look? Look for a higher CRI (Colour Rendering Index) number. 100 = best. I usually won't use anything less than 80 and even that's pushing things. I prefer 90+
Colour of light? Look for the Colour Temperature spec. 2700K is supposedly equivalent to incandescent, 3000K-3500K is supposedly halogen, 5000K is supposedly daylight at high noon. I say supposedly because the CRI mentioned above + colour temperature greatly influences how things look. A standard fluorescent 3500K does NOT look the same as a halogen.
Light pattern/bulb style? Are you replacing a flood/spot/reflector bulb? A standard omnidirectional (type A) bulb? Too many variables here. Spots/floods come in all sorts of widths and patterns. Same goes for the Type A bulbs. Some Type A LED replacement bulbs are good at shooting light in a near-perfect sphere. Others only are good at shooting it straight up.
Longevity? Look for higher hours....BUT realize that many of these figures are bull, and the cheaper co's will spec what the LED element manufacturer's spec sheet says rather than actual testing. Heat destroys LEDs and electronics, so the better a bulb is able to get rid of heat, the longer it will last. Overheated LEDs also have the tendency to age and grow dimmer over time.
Dimmable? Not all LED bulbs are dimmable. Those which are vary in just how exactly they dim. Some are smooth, others not so much.
I wish there was a simple answer, but without more context it's only possible to offer generalities.