If it's a dedicated home defense gun, I'd go with the Surefire. If it's also a carry gun, and you plan to take the light on and off alot, then the M3 makes more sense. There have been failures with the contacts inside the M3 on guns that are shot alot with the light on.
It's a tough call, I just went thru this decision process myself so I know your dilemma. I hate the fact that I have to mount different rails on my gun. But, I also want it to be 100% reliable and I want to practice enough with the light so I know that I, and it, are reliable. Yet it's the practice which wears out the M3. So, I was afraid I wouldn't trust it when and if the time came.
I will be glad when all the gun manufacturers finally settle on a common rail, like a picatinny rail, so everyone can make lights that work on all the guns and we can have better choices.