Ahw, welcome to CPF. You pose an interesting question.
My XO3's beam is slightly tighter than my EDC/always-in-my pocket E2L. The rugged Inova does appear to have slightly better throw. Beamshots-on-a-white-wall won't tell you very much re either light for practical purposes. You're probably more likely to have that smaller E2L with you, however, when the Spit Hits The Fan in a dark parking lot "tactical situation" and Rosie O'Donnell ain't around to defend you.
As to Self Defense use, that's a big can of worms with ideological overtones -- and one that always leads to hotly politicized debate. Why? Because a potent flashlight alone is a pi$$ poor self defense tool which only those who believe in the Tooth Fairy (and the pacifist-elitist agenda) actually hope to have some practical effect on a miscreant -- without the accompanying threat of (your) immediate countervailing violence behind it.
IF you COMBINE a good light with:
1. Heightened Situational Awareness
2. Rejection of prevailing P.C. academic/cultural conditioning re "fighting back"
3. A combative/warrior Mindset (determination to NEVER be a victim)
4. An effective Weapon, and
5. The Training to maximize that weapon under stress...
... then you'll be prepared for The Real World.
If you labor under delusions that some flashlight exists which willl enable you to magically neutralize Street Punks without bloodying your own hands, then take two Valiums, make a donation to Cindy Sheehan's Mommies For The Terminally Naive, and call me in the morning. And, if you're a street-smart LEO, you'll find better lights that either of these for primary tactical use.
I urge you to (a) spend some time using the Search feature here re "Self Defense," and (b) thoroughly read the late/esteemed Col. Jeff Cooper's little classic "Principles Of Personal Defense."
Bottom line: a good flashlight is really only an "early-warning radar" tool for enabling you to spot and fix potential Targets. OR, to warn 'em that you ain't some ditz-brained, quiche-eating sheeple that's ripe for their fleecing.