If you do enough things wrong, li-ions in series can go excitingly wrong. The same is true of fireworks, dogs, and pencils. If you have mis-matched, unprotected cells AND one dies before the others, AND it reverse-charges and heats up, AND enters a runaway reaction, you will have some extent of problem (Failed light to small toxic explosion). This usually happens when a user inadvertently mixes a fresh and old cell (Whether li-ion or lithium). Given the number of loose cells in the world, this is a rather rare occurrence. Don't go home and throw all you Lithium cells in a fireproof safe; they work pretty well.
Why higher-voltage drivers? Well, an LED really only takes about 3.5v per LED in series. But incandescent torches tend to be more powerful at higher voltage, and some LED drop-ins are meant to be direct replacements. And hey, "I can take all the volts" is a good feature to claim. Sometimes it gives better battery life. In theory, you can convert 100 mA at 18v into 600 mA at 3v, but the drivers aren't 100% efficient.
In these cases, you could set up a buck driver light with quality, fresh CR123s, and put it in a box for ten years and still have quite a bit of life left in it. However, not all drivers are created equal. Some drivers actually just throw away the extra voltage as heat!