I still have some E2es, but I use the L4 more because the L4 is regulated and uses Pila 168S batteries.
The Surefire A2 is another replacement for the E2e. You might want to consider the L2 also.
The E2e was the obvious choice before the L4,A2,L2 came out because of size vs brightness. The E2e is as good as ever, but now we have more choices.
The answer to your question is: yes the L4 replaced the E2e for my use. I am using a L4 with a Pila 168S & a ARC 4x with a R123 for my EDC because of the rechargeable batteries.
I actually went from EDCing a E2e, ARC LSH-P & a ARC AAA to carrying a A2, ARC LSH-P, ARC AAA. I carried the A2 for about 18 months and only switched to a X bin PR and then the L4 because I could use Pila batteries.
If I weren't using Pila batteries I would use either the A2 or L2.