Thanks, Tom. I don't actually drive a big truck, I drive a Sprinter cargo van, so the entire van is essentially the cab. But the only real difference is the amount of freight I can haul. I have room for two pallets (expedited freight), and the forward section of the van is the bunk and driving area. So the back half of the van is all cargo, and the front half is like an RV.
Venting the cab is not a problem, as I have a roof vent fan that is on most of the time, but is certainly open (with the fan running) when I'm charging NiMh batteries, and will be the case with Li-On batteries, as well. Under the bunk I have large Trojan wet cell batteries which can vent when charged, so airflow and ventilation is something that's always an important factor in here. The rood vent van can be opened and the fan running in about 5 seconds. It's operated with a remote control (or can be hand cranked opened and closed). There is also a side sliding door that can be opened quickly. A fire extinguisher is within easy reach whether driving or sitting still. The van contains both oxygen monoxide and smoke detectors.
For charging Eneloops, I usually just leave the charger on a shelf of a little desk-like thing that is where the passenger seat used to be, and power the charger off the inverter. I'm very confident in the charger for Eneloops. Although, interestingly, when I charge four at the same time (or two in paired bays), the Eneloops get rather hot. Not too hot to touch, but it's close. When I charge them one or two at a time in non-paired bays, they remain at room temperature.
For Li-On batteries I'll usually be powering it directly from a 12-volt plug connected to the battery bank. The reason is, I can set the charger in a little nook between the fridge and the bunk, on top of a metal briefcase. That way, if there is an explosive event, any shrapnel will miss me if I'm driving or in the bunk sleeping. It would be like you said, across the van.
I probably won't charge Li-On cells while driving for at least the first several charges, not until I know what to expect with them. Same with charging while sleeping. I will get a Lipo Sack just because. Couldn't hurt.
I know and understand large batteries very well. Cranking, deep cycle, marine "deep cycle" hybrids, wet cell, AGM, gel, you name it. The old adage that "batteries don't die, their owners kill them" is one of which I'm very familiar. But smaller batteries are a little different. While many of the "care and feeding" concepts translate to small battery chemistries, there are still some subtle differences that I'm still learning.
The battery bank under the bunk.
You can see a little of the roof vent fan at the top. The briefcase there is an old one (it's an older pic). The new one is metal. That's the nook where the charger will be. On the right there is the wood desk. the cutout where the wires protrude is where I set the charger for NiHm charging. The carpet, not to mention the bedding material, is one of the reasons I'm strongly considering a Lipo Sack.