Kuse et al. reported that 661W cells are more sensitive to light-induced damage when exposed to light emitted by blue (464 nm) LEDs than when exposed to green (522 nm) or white LEDs (wavelength peak at 456 and 553 nm) of the same intensity (0.38 mW/cm2). The exposure to blue light, unlike the exposure to white and green LEDs, also produced a significant increase in ROS and induced cell damage. Similar results were also observed in primary retinal cells. These data support the idea that exposure to blue light in the range of 400–470 nm (even at low levels) may damage photoreceptors and retinal pigment epithelium cells.
I think this section makes my point nicely. You are I both know that that white LED contains a significant portion of light from the exact spectrum of a blue LED. However, they claimed that the blue LED produced a significant increase in ROS and cell damage, while the white did not. Now how much different was that damage? 10x ?? Was it a direct correlation of intensity of light in the damaging portion of the spectrum?
The other issue with these studies is they don't do enough studies at various intensities to determine if the damage level is linear or not. That is pretty critical as it could set far more effectively a "safe" level.
This brings me back to the original study you posted where 500 lux directly at the eyes was used, a value far outside "normal", and perhaps at a level that is not relevant if the level of damage at a realistic levels is not well understood (and proper CCT light was not used, and comparison sources not detailed).
... AND as we both noted, while LED bulbs at 80 CRI do have higher levels of blue, it's not as large as most people think, and LED bulbs have no very short blue, but incandescent does.
Heck, most of these studies do not even look at relative exposure to interior light and being outside for an hour or two. Maybe the people we need to worry about most are garbage collectors?
Really though, I worry most about looking at my computer screen .... one of the reasons I keep my light level high in the room as it forces pupil closure reducing exposure level (and improving focus).