I don't think you're particularly asking for too much. Are you working with some kind of big commercial battery off a forklift or something? What you are asking for is certainly technically possible, and 48 volts would be better than 12 if you had to send power to different buildings around the property.
My thought was that in the 12 volt neighborhood you have lots of ready made parts and components, all you have to do is place an order and let them ship stock items. I think you may need components built to order if you want to work in the 48 V neighborhood. One thing you might consider is to order one custom part, a 48V -> 12V converter right by the battery, and then 12 v. around the house, all of it easy to work with.
The actual LEDs themselves will mostly only need two or three volts to run them, so you're probably going to need to step down your power somewhere along the line anyway. Are there any circumstances where you might not want all ten or twenty lights on at the same time? If they are all in one big series you won't really be able to dim or run them separately.
If you care to discuss it, I would also be interested to hear what kind of wire you plan to run, how you plan to run it, and what kind of connectors you plan to use. I have done some work with 12 volt LED lighting and found that lampcord works nicely from a technical standpoint, but it doesn't seem to be considered proper to run in walls.