As far as I know, and in my own experience, CR123 primaries are the least likely cells to leak, regardless of their state of charge. The one possible exception would be the 1.7 Volt AA and AAA lithium primaries, as they have yet another form of lithium chemistry. They may be even better, I'm not sure, as I have never had either chemistry leak.
The one thing, as you probably already know, is that you don't want to mix partially discharged lithium primary cells that have been used in single cell applications, together in a series application. I'm not to sure about leaking in such a situation, but this can be dangerous, as far as "venting with flame", which I would consider extreme leakage! :poof:
Dave