Spyware doesn't affect Macs. Here's my cleaning routine for PCs:
Background--this post was made somewhere else. The person was considering calling Norton for help.
You've run virus scans but you've still got
Spyware. I *HATE* this stuff. I used to get to tell people to call Dell to get it fixed, but now I have to actually help them with it. Before you call Norton do the following:
Download and run
AdAware
Reboot, update the definition/scanning rules, scan again.
Then download and run
SpyBot. SpyBot will run on your system and try to keep the Spyware from getting in, but it's still a good idea to update definitions in those programs weekly and scan. Doesn't take long, 5-10 minutes.
Finally, run the free web-based scan found
here. It's not as thorough as AdAware or Spybot, but it will catch some things that both of those missed.
More Info
If none of that works than you're pretty much stuck with reinstall windows/buy a Mac/install Linux/go Amish/etc.