The best piranha LEDs I've seen so far (
Nichia part number NSPWR70SS) put out about 4 lumens at 20 mA. At 30 mA they would give about 35% more, or roughly 5.4 lumens. 600 of them would give you 3240 lumens, or about 20% more than one 32W 4-foot T-8 fluorescent tube. Power consumption would be roughly 0.03A x 3.8V x 600 = 68.4 watts plus the losses in the driver circuit.
Nix the idea of mixing in yellow LEDs. I've been down that road on a smaller scale when trying to light HO passenger cars. First, it'll hurt the efficiency. Second, there will definitely be unevenness in the light pattern from the mixing. Third, if you get the C0 bin by Nichia it'll give a CCT of ~5000K instead of the usual too blue 8000K of most white LEDs. 5000K is just about perfect for general lighting-not too yellow, not too blue, just a nice, pure white.
As much as I love LEDs, in all honesty if you want to light a room 5000K T-8 fluorescent is the best, most efficient way to go. You'll use about half the power of even the best LEDs, and will get superior color rendering and much more consistent color temperature. LEDs just aren't quite there yet for general lighting although I expect that we'll see LED screw-in incandescent replacements hitting the shelves within a few years. It'll be a long time though before LED becomes cheap enough and efficient enough to compete with today's fluorescents.