I had to take a class on seizures a while back when I was working with adults with disabilities. I remember being told that anyone can have a seizure if they're tired enough and they see flickering lights at the right frequency. The example the instructor used was to think of someone who's been up for a day or so, unable to sleep, sitting on the couch/recliner watching tv late at night in a dim room...they're a prime target to have a light-induced seizure.
I know it's not safe to drive tired, but I'm sure we all have at some point...