Ive researched this a LOT, so here is what I recomnend.
Firstly use a CC driver. Removes so much hassle and calculation and headscratching.
Second decide what mA you want to run the LEDs at. I reccomend 350, since they run much cooler for not THAT much less light (output curve is not linear)
Thirdly decide how many LEDs. Then find a suitable driver. Lots of different naming conventions out there that can be confusing. SO lets say in your example, you run 4 Crees at 350mA (which equates to about 1W power rating for each Cree). So you need a minimum 4W CC driver. Or if you look at DX they would label it as 4X1W.
If you get a higher powered one (8W or so drivers are common) you need to check one thing, and thats the MINIMUM output voltage. Some Xitaniums for example have a MIN V of 16V so you have to be careful you dont connect 3 LEDs only or they will blow. One driver on DX has a minimum Vout of 40V, so u need at least 10 LEDs connected to begin with.
Rule of thumb, if its a proper CC driver, you should be able to safely connect any number of LEDs whose combined voltage in series falls in the Vmin Vmax range of the driver.
Is this clear enough for you? If not ask away.
I learnt all this looking at datasheets and asking here, so look at some Xitanium datasheets, and you will soon start getting your head around it. Good luck!