From what I've read, using the MC-E (wired 2S2P) is a great upgrade for the older U2's that use the LuxV emitter - the older U2 driver is apparently excellent match to the MC-E. There are some good threads here depicting that mod.
The newer U2's that use the SSC P4 emitter (with the lower Vf) are not as good of an upgrade candidate IMO. I know much less of these - the older ones sound like a better platform to me.