I'd wager all the manned aircraft introduced after the F-117 will be viewed as a mistake..
An Air Force General told me that he views all fast/high manned aircraft as anacronysms. Endurance of manned recon flights are limited no matter how fast or high they fly. High unmanned recon flights are up to 24hrs now.
However the winner of unmanned flight duration is the X-37B: now set for launch #4 on 20 May. More importantly, the USAF is progressively giving away some of the X-37B testing involved, other than recon. specifically, thruster experiments involving electric propulsion, eg: ION propulsion already deployed in the very latest recon satellites. This translates to a much longer operational life for those very expensive recon satellites (usually the KH series).
If anyone is interested,
here is a 262 page PDF on an early series of those KH satellites. Of course, the NRO is the sponsoring organization.
Also, if anyone remembers, the presumed "Aurora", or whatever real name it had we will never know - an early follow-on to the SR-71 - evidently used pulse-jet (popcorn-on-a-string contrails) propulsion and was rumored to employ ionic/plasma flow enhancement on the leading edges to enhance the speed well beyond the SR-71. At least two deployments of this A/C series were noted by observing the unique contrails. Both deployments ceased some years ago.
Now the long-expected SR-72 is showing up in the news again. This time rather than a 2-stage engine (turbo + ramjet bypass) of the SR-71, the SR-72 is rumored to be designed with a 3-stage engine (turbo + ramjet + scramjet). Mach 6 has been the stated design speed. Most air-to-air missiles have a max speed of Mach-5, some of the fastest might make it to Mach 6. However the altitude difference would render the SR-72 even less challenged than the SR-71 was by air-to-air missiles. 80K feet is still evidently the mission altitude, same as the SR-71. Even though many A-A missiles & SAM missiles were launched, none even came close to the SR-71. As the SR-71 pilot of the last speed-setting event stated, (paraphrased) 'we flew fast enough to break the old record, not as fast as we could'.
side note: FAA control ceases at flight level FL 600 (60,000 feet). After that, any pilot up there is on his own. Recent reports of contrails well above FL 800 have been reported. Go figure.