With that sort of insane budget I would seriously suggest seeking out advice on forums that are more dedicated to the topic matter. While CPF is chock full of great minds there isn't going to be as much useful advice as easily possible here.
Post your query over at overclock.net to get some more input.
My advice is as follows:
Build it!
Pro apps like autocad and solidworks and many other powerful creations apps will run really well on machines with FAR LESS budget than what you have in mind here. An i5 quad sandy bridge paired with a GTS450 and a nice 16GB kit makes for a pretty inexpensive build that will power through all the modern pro apps very well. If you want to pay for better GPU integration in the pro apps, the "quadro 2000" GPU is just a under-clocked GTS450 with it's BIOS flashed to register as a Quadro series instead of a GeForce series, and sold at about 5X the cost with the pro drivers that allow the GPU to integrate better into a handful of pro apps. in theory, in time, a driver kit may come along (non-supported) that would make a GTS450 work as a quadro 2000. That's theoretical. If you intend to spend more to gain GPU performance, forget about multi-"gaming" GPU configurations as there are not going to be any SLI or CFX profiles in the non-professional drivers, just buy a workstation GPU, or bite the bullet and go with SLI worktation GPUs. They can be pricey but for those who are really dealing super complex models frequently they can be a blessing. Before doing an SLI quadro configuration, make sure the pro apps you are using will take advantage. Nvidia has to have an SLI profile built into the driver for each app, if it's not supported then don't bother. See the following:
http://www.nvidia.com/object/quadro_sli_rendering.html <notice how some apps in the list there get no benifit.
Did I mention Build It? Oh right... BUILD IT!
Pick a quality PSU. Very much like BS lumen ratings, many PSUs are BS as well. Pick a PSU carefully: Most Corsair, Seasonic, PC Power&Cooling, some OCZ units, most XFX. It's not about having the most wattage available, it's about providing reliable clean power. The PSU is often the most overlooked but most likely to fail if you cheap out.
Pick a MOBO with really hefty VRMs to power the CPU to maximize long term reliability of the board. Many are lacking. Look for boards with lots of VRM "units" surrounding the CPU socket, and, ideally, with heat sinks. Higher end Gigabyte and Asus brand boards tend to be very good choices these days. You can learn more about VRM quality through some of the sticky threads on overclock.net
The budget has plenty of room for an i7-3930K, I'd be tempted to go for it. I don't think I would worry about a dual socket board.
Bulldozer is a flop, don't bother.
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I would do the following (or something similar) with a 5K budget:
http://www.newegg.com/Product/ComboDealDetails.aspx?ItemList=Combo.772175
This budget has room for the new high density DDR3, may as well go big. Decent mobo there also.
http://www.newegg.com/Product/ComboDealDetails.aspx?ItemList=Combo.785666
Overkill PSU and worlds first single platter 1TB mechy drive. (The system will probably never draw more than 350W total, but I saw this combo so thought I'd throw it in there)
http://www.newegg.com/Product/ComboDealDetails.aspx?ItemList=Combo.776311
CPU and a well made case. A dual 1366 xeon build is certainly an option, however, you pretty much have to plan on about 3-5X the CPU cost for less than double the performance. That would be a tough one for me to swollow. Also wouldn't be a bad idea to see how many cores the pro apps you will be using can scale up to. Most will use as many cores as you have available but some won't.
http://www.newegg.com/Product/Product.aspx?Item=N82E16822145533
Second mechy drive for backup, either use as a manual backup or configure in RAID0 with the other drive.
Flooding in thialand a couple months back has mechy HD prices very high... nothing you can do about it but bite the bullet.
http://www.newegg.com/Product/Product.aspx?Item=N82E16820147137
Use this as the boot and apps drive to maximize loading speed. Some people also like to use their SSD space for "current project" which would not be a bad idea. Back up to mechy drives frequently.
http://www.newegg.com/Product/Product.aspx?Item=N82E16814133325
Technically speaking, that is a GTX465 with a pile of extra memory and lower clock speed and the ability to use the pro drivers enabled, being sold for ~15X the price of a GTX465. I would spend some serious time analizing whether or not the pro drivers are going to provide enough benifits to be worth it for the specific appliation. This card does support SLI. A quadro 2000 would save a lot of money but is not SLI capable so does not provide a very good upgrade path.
Pick out a nice $20 DVD burner and you have a machine..
Under $3,700, not bad...